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PVA/Hydroxyapatite composite nanofiber for bone tissue engineering

Nanostructure, porosity and tensile strength of PVA/Hydroxyapatite composite nanofiber for bone tissue engineering

Hydroxyapatite [HAp, Ca10(PO4)6(OH)2] was successfully synthesized using natural minerals, precisely limestone from Druju Indonesia. As a bone scaffold compound, HAp has a weakness of low mechanical properties therefore it needs to be mixed with polymeric materials, such as polyvinyl alcohol (PVA) to improve its mechanical properties. The PVA/HAp composites nanofiber have successfully synthesized using the electrospinning method and analyzed including nanostructure, porosity and tensile strength of nanofiber. The diameter of PVA/HAp composites nanofiber in 173 to 234 nm, porosity in 62 to 74%, and tensile strength in 6.96 to 15.85 MPa. Increasing of HAp cocentrasion increase of tensile strength, SEM showed an increase in HAp concentration (0%−20%) causing a decrease in the average diameter of the fiber. The characteristics of PVA/HAp composite nanofiber can be applied as a scaffold in bone tissue engineering.1


Nanostucture and distribution of fiber diameter to the composition of PVA/HAp (a) 100/0 (b) 90/10 (c) 85/15 (d) 80/20 (e) 75/25 and (f) 70/30.
Nanostucture and distribution of fiber diameter to the composition of PVA/HAp

Distribution of mean diameter fiber.
Distribution of mean diameter fiber.

1. Hartatiek, Yudyanto, M.I. Wuriantika, Joko Utomo, M. Nurhuda, Masruroh, D.J.D.H. Santjojo,

Nanostructure, porosity and tensile strength of PVA/Hydroxyapatite composite nanofiber for bone tissue engineering,

Materials Today: Proceedings,

2021,

,

ISSN 2214-7853,

https://doi.org/10.1016/j.matpr.2020.11.438.