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Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

Microporous annealed particle (MAP) scaffolds are microporous scaffolds consisting of cross-linked, fluid, and microgel building blocks. Previous studies have shown that these scaffolding accelerate wound healing. This research, published in Nature, aimed to slow the degradation of these scaffolds after scaffold degradation by altering the chirality (L-D) of the crosslinked peptides to enable tissue development. According to the results of the study, material degradation was accelerated in vivo by D-MAP(d-peptide cross-linked map hydrogel), although it showed a slow enzymatic degradation in vitro. It also provided significant tissue regeneration to cutaneous wounds. These MAP construction scaffolds collect IL-33 type 2 myeloid cells that multiply in the presence of d-peptides. In the study, d-MAP revealed a significant immune response to peptides. In order for hydrogel-stimulated skin to regenerate, an adaptive immune system is required. The biomaterial is sufficient to generate the immune response and increase the rate of scaffold degradation to stimulate healing.