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Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

Writer: kübra:)kübra:)
Dec 11, 20201 min read

Microporous annealed particle (MAP) scaffolds are microporous scaffolds consisting of cross-linked, fluid, and microgel building blocks. Previous studies have shown that these scaffolding accelerate wound healing. This research, published in Nature, aimed to slow the degradation of these scaffolds after scaffold degradation by altering the chirality (L-D) of the crosslinked peptides to enable tissue development. According to the results of the study, material degradation was accelerated in vivo by D-MAP(d-peptide cross-linked map hydrogel), although it showed a slow enzymatic degradation in vitro. It also provided significant tissue regeneration to cutaneous wounds. These MAP construction scaffolds collect IL-33 type 2 myeloid cells that multiply in the presence of d-peptides. In the study, d-MAP revealed a significant immune response to peptides. In order for hydrogel-stimulated skin to regenerate, an adaptive immune system is required. The biomaterial is sufficient to generate the immune response and increase the rate of scaffold degradation to stimulate healing.


| d-MAP changes the wound fate from scar formation to regeneration by type 2 immune activation. a, Representation of the MMP cleavage sequences, amino acid chirality within the crosslinking peptides and microfluidic formation of the hydrogel microbeads that incorporate l- or d-chirality peptides. b, The use of l- or d-MAP in a wound-healing model demonstrates that both the l-MAP (green) and d-MAP (red) hydrogels fill the wound defect. Wounds that heal in the absence of a hydrogel heal with an atrophic scar and loss of tissue (top row), whereas the epidermis forms over the scaffold with both l- and d-MAP and allows an increased dermal thickness (middle two rows). However, in the case of d-MAP, the hydrogel activates the adaptive immune system over time, which results in tissue remodelling and skin regeneration as the adaptive immune system degrades the d-MAP scaffold (bottom row). PEG, polyethylene glycol.
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.

 

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